ABC
11/04/1910
Madrid premiere of the world's first facility to produce artificial organs
still do not beat or pump blood, but in the Gregorio Maranon Hospital in Madrid and there are eight human hearts ready. Bioartificial organs are manufactured from the original structure of a heart that has been stripped of all cardiac cells to leave bare. After inoculation of the patient's stem cells to be transplanted the heart does go back to life. At least that is what has occurred in animal experiments. The cardiologist Francisco Fernandez-Avilés hopes that by the end of the year, at least a portion one of these human hearts created in Spain will be functional and demonstrates its ability to beat. This was announced at the launch in Madrid hospital of the first facilities in the world which will host the exclusive this pioneering research.
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It's "an unprecedented" of regenerative medicine and the English investigation, said Fernandez-Avilés. Gregorio Marañón
The bank hopes to manage with "templates" or structures of human and animal organs, ready for transplantation and as of each patient. After
enough to take stem cells from a patient and repopulate them one of these patterns to get a new organ without risk of rejection by the body, or waiting lists. Several research groups worldwide working on this line, but Madrid has become the first city to be encouraged to create a laboratory for this purpose only. Installed in the basement of the new hospital building, has received an initial investment of 600,000 euros and the support of the Community of Madrid, the Ministry of Science and the National Transplant Organization (ONT). The three institutions supported the inauguration with the presence of the Minister Cristina Garmendia, the Madrid president Esperanza Aguirre and Rafael Matesanz, director of the ONT.
The first mouse
Fernández-Avilés cardiologist will head a team of ten people who work in close collaboration with the University of Minnesota and Dr. Doris Taylor. This research was the first to get a bioartificial heart mouse, able to beat and pump blood. After Taylor moved the research to human organs in Spain. With the team of Gregorio Marañón, were the first to eliminate all cells of a human heart and keep only its structure. This first step to create first artificial organ was last May. Six months later, there are eight hearts ready and one more in process.
The next step is to grow stem cells one of these templates perfect that only nature provides to check if it is functional. That will happen before year's end, although Taylor's opinion "could make it next week." Six months later she may try the first transplants in animals and in five years to prove with the first patient.
Gregorio Marañón The team has clear time, not so much the type of cells used to repopulate and customize each organ. "We should discuss whether the source of stem cells is fat, bone marrow, the heart itself or maybe if you chose to reprogrammed cells, Fernandez-Aviles said. First generate Hearts - "the organ that we know best" - and then livers, kidneys and other organs.
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