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02/11/1910 A study by the Karolinska Institute in Stockholm (Sweden), which is published in the online edition of the journal Proceedings of the National Academy of Sciences' ( PNAS). The researchers could monitor the progress of aging by measuring levels of lactic acid in the brain. Researchers have long suspected that aging s and produced from gradual damage to mitochondrial DNA, the genetic material needed to produce energy from food.
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Previous studies have linked mutations in human mitochondrial DNA in the central nervous system disorders associated with aging such as Alzheimer's and Parkinson's. The scientists, led by Lars Olson, investigated this theory by examining the metabolic processes of the brain of aged mice advanced normal and premature aging.
The researchers found that mitochondrial DNA damage triggers a metabolic change in the brains of mice that may alter the expression of certain genes that control the formation of lactic acid.
According to the authors, this change results in a higher lactic acid levels in the brain that could be detected using noninvasive imaging techniques. The findings also suggest that lactic acid levels rise before other indicators of aging and, in the absence of further research could be used to detect age-associated diseases central nervous system.
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